By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the titanic physique of uncomplicated technological know-how and medical facts linked to adenomatous polyps of the colon, a lot of it encouraged through the conclusion that the majority colorectal carcinomas appear to come up in such polyps. This e-book strives to judge those information, with specific emphasis on their implications for administration of polyp-bearing topics. subject matters comprehensively explored contain anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential analysis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant strength of adenomatous polyps; and detection and administration, with exact recognition to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Extra resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
In P Sherlock, BC Morson, L Barbara, U Veronesi (eds): Precancerous Lesions ofthe Gastrointestinal Tract. Raven Press, New York, pp 127-135. Grinnell RS, Lane N (1958) Benign and malignant adenomatous polyps and papillary adenomas of the colon and rectum. An analysis of 1,856 tumors in 1,335 patients. Int Abst Surg 106:519-538. Haggitt RC, Reid BJ (1986) Hereditary gastrointestinal polyposis syndromes. Am J Surg Pathol 10:871-887. Hamada S, Namura K, Fujita S (1988) The possibility of nonpolypoid carcinogenesis in the large intestine as inferred from frequencies of DNA aneuploidy of polypoid and crater-shaped carcinomas.
One investigator found that APs maintained for 3-14 days in a fibrin foam matrix showed histological progression into in situ and then invasive carcinoma (Kalus, 1972). This observation provides strong support for the adenoma-carcinoma sequence but unfortunately has not been described in subsequent reports by others. 6. , 1960; Enterline & Arvan, 1967). The latter group demonstrated chromosomal abnormalities consistently in APs: Hyperploidy and structurally abnormal individual chromosomes were more common in the more severely dysplastic or villous tumors.
Jothy S, Boucher L, Fuks A (1988) Differential expression of CEA epitopes in colonic polyps correlates with histopathological features. Lab Invest 58:44A. 40 2. Pathology Kalus M (1972) Carcinoma and adenomatous polyps of the colon and rectum in biopsy and organ tissue culture. Cancer 30:972-982. Kanemitsu T, Koike A, Yamamoto S (1985) Study of the cell proliferation kinetics in ulcerative colitis, adenomatous polyps and cancer. Cancer 56: 1094-1098. Kaye GI, Pascal RR, Lane N (1971) The colonic pericryptal fibroblast sheath: Replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue.