By L. Chedid, J. W. Hadden, P. Dukor, D. A. Willoughby and F. Spreafico (Eds.)
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Extra info for Advances in Immunopharmacology. Proceedings of the Third International Conference on Immunopharmacology, Florence, Italy, 6–9 May 1985
M. Staub, C. Galanos, O. Lüderitz (1982). Eur. J . Biochem. J 2 5 4 3 1 - 4 3 6 . H. R a e t z (1981). J . Biol. Chem. 236 10690-10696. , F . Amano, A. Minoura, Y . H. R a e t z (1984). In: Bacterial Endotoxins: Chemical, Biological and Clinical Aspects. (Homma, J . Y . Kanegasaki, S. Lüderitz, O. Shiba, Τ. Westphal O. ) Verlag Chemie, Weinheim. pp. 2 3 - 2 8 . Nowotny, Α. (1961). J . Am. Chem. Soc. 83 3 0 1 - 3 0 3 . Nowotny, A. (1971). In: Microbial Toxins (G. Weinbaum, S. Kadis, S . J . ) VoL IV.
5 4 7 - 5 5 1 . Yamamura, Y . , I. Azuma, Μ. Yamawaki, Μ. U e m i y a , F . H i r a o , Τ . Y o s h i m o t o , Μ. Namba, R. Tokuzen and K. Kusumoto ( 1 9 7 9 a ) . Immunotherapy o f c a n c e r w i t h the c e l l - w a l l s k e l e t o n of N o c a r d i a . In Immunobiology and Immunotherapy o f C a n c e r , E l s e v i e r / N o r t h - H o l l a n d P u b l i s h e r s , New Y o r k , p p . 2 7 9 - 3 0 9 . Yamamura, Y . , T . O g u r a , M. S a k a t a n i , F . H i r a o , S . K i s h i m o t o .
Comparative data for lethal toxicity (Tab. 2), pyrogenicity (Fig. 7), and local Shwartzman reactivity (Tab. coli type) a r e presented. Table 3 Induction of local Shwartzman reaction by synthetic and natural E . coli lipid A. 1 +++ +++ ++ + +++ ++ + With the successful total synthesis of the complete lipid A of E . coli a long story has found a rewarding "happy end". In the future many questions concerning endotoxin and the many "endotoxic" reactions of higher animals can now be studied with pure synthetic products including derivatives and analogues of the natural prototype (which may also be radio-labelled).