By N. M. Hooper
A panel of hugely expert investigators describe intimately their cutting-edge biochemical, mobilephone organic, and molecular organic suggestions for learning the molecular foundation of Alzheimer's affliction. those comfortably reproducible, step by step tools specialise in paintings with the amyloid precursor protein and the amyloidogenic peptide A?, but additionally include-with the hot identity of presenilin proteins-techniques for picking the constitution and organic functionality of those proteins. furthermore, there are chapters masking the tau protein and its position in Alzheimer's ailment, in addition to an introductory dialogue of the background of the sickness, its genetic foundation, and the presently on hand and attainable destiny healing brokers. state-of-the-art and large ranging, Alzheimer's illness: tools and Protocols presents prepared entry to confirmed, reproducible equipment for elucidating the molecular foundation of this most typical senile dementia.
Read or Download Alzheimer's Disease: Methods and Protocols (Methods in Molecular Medicine) PDF
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Additional info for Alzheimer's Disease: Methods and Protocols (Methods in Molecular Medicine)
Strittmatter, W. , and Roses,A. D. (1993) Apolipoprotein E-highavidity binding to beta-amyloid and increased frequency of type-4 allele in late-onset familial Alzheimer-disease. Proc. Natl. Acad. Sci. USA 90,1977-1 981. 22. Saunders, A. , Strittmatter, W. , St. George-Hyslop, P. , Pericak-Vance, M. , Joo, S. , et al. (1993) Association of Apolipoprotein E allele E4 with the late onset familial and sporadic Alzheimer’s disease. Neurology 43,1467-1472. 23. Corder, E. , Saunders,A. , Strittmatter, W.
Science 269,973-977. 105. Borchelt, D. , Eckman, C. , Lee, M. , et al. (1996) Familial Alzheimer’s disease-linked presenilin 1 variant Neuron 17, 1005-1013. elevate AP 1-42/1-40 ratio in vitro and in vivo. 106. Mehta, N. , L. , et al. (1 998) Increased AP42(43) from cell lines expressing presenilin 1 mutation Ann. Neurol. 43,256-258. 107. , Lendon,C. , et al. Nature 393,702-705. , 108. , Bird, T. , Garruto, R. , Anderson, et al. (1998) Tau is a candidate gene for chromosome 17 frontotemporal dementia Ann.
Et al. (1990) Transmission and age at onset patterns in familial Alzheimer’s disease: evidence of heterogeneity. Neurology 40,395-403. 17. Pericak-Vance, M. , Bass, M. , Yamaoka, L. , Gaskell P. , Scott, W. , Terwedow, H. , et al. (1997) Complete genomic screen in late onset familial Alzheimer’s disease. Evidence for a new locus on chromosome 12. JAMA 278, 1237-1241. 18. , Song,Y. ,et al. (1998) Evidence foran Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.