Alzheimer's Disease: Methods and Protocols (Methods in by N. M. Hooper

By N. M. Hooper

A panel of hugely expert investigators describe intimately their cutting-edge biochemical, mobilephone organic, and molecular organic suggestions for learning the molecular foundation of Alzheimer's affliction. those comfortably reproducible, step by step tools specialise in paintings with the amyloid precursor protein and the amyloidogenic peptide A?, but additionally include-with the hot identity of presenilin proteins-techniques for picking the constitution and organic functionality of those proteins. furthermore, there are chapters masking the tau protein and its position in Alzheimer's ailment, in addition to an introductory dialogue of the background of the sickness, its genetic foundation, and the presently on hand and attainable destiny healing brokers. state-of-the-art and large ranging, Alzheimer's illness: tools and Protocols presents prepared entry to confirmed, reproducible equipment for elucidating the molecular foundation of this most typical senile dementia.

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Et al. (1990) Transmission and age at onset patterns in familial Alzheimer’s disease: evidence of heterogeneity. Neurology 40,395-403. 17. Pericak-Vance, M. , Bass, M. , Yamaoka, L. , Gaskell P. , Scott, W. , Terwedow, H. , et al. (1997) Complete genomic screen in late onset familial Alzheimer’s disease. Evidence for a new locus on chromosome 12. JAMA 278, 1237-1241. 18. , Song,Y. ,et al. (1998) Evidence foran Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.

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